Nano-particle sizing and Zeta Potential

MALVERN ZETASIZER NANO -ZS

0.6nm to 6000nm particle sizing plus Zeta potential

This multi purpose desktop analyser combines the capability of static and dynamic light scattering, plus Zeta potential. Sizing of nano-particles from 0.6 to 6000nm is now extremely simple and rapid, with highly repeatable measurements. The novel non invasive backscatter (NIBS) optics provides exceptional sensitivity to size molecules smaller than 1000 Daltons.

Samples at concentrations up to 20vol% ( equivalent to 40wt%) have been analysed without dilution. This possibility of non destructive analysis enables the original nature of the sample to be preserved. The system is also exceptionally sensitive and can measure small quantities of sample, including those as dilute as 0.1ppm. Precision temperature control from 2 to 90 Deg C ensures highly repeatable results.

Zeta potential is measured by the patented M3-PALS technology, giving the highest ever sensitivity and resolution. Cross contamination is eliminated by means of a unique disposable capillary cell. For non aqueous applications there is a re useable dip cell. Measuring Zeta potential as a function of pH, conductivity or additive can be automated with the optional autotitrator.

The software provides fully automated operation, including generating Standard Operating Procedures, temperature and time trend analysis, a full range of statistical plots and custom report generator. Malvern provide comprehensive validation support and all systems comply with 21 CFR part 11.

The Zetasizer nano series using NIBS comprises the model S for size measurement, model Z for Zeta potential and model ZS for both size and zeta potential. Conventional 90 deg measurements are made with models S90 and ZS90.

Chromatography detector

A new chromatography flow-mode for the Zetasizer-nano enables it to be also used as a highly sensitive size exclusion chromatography detector. This enhanced capability provides a major new tool for protein and other biomolecular research.

This new capability is available to existing Zetasizer-nano customers.
Simply purchase a flow cell and download a free software upgrade.

chromatography flow-mode combines dynamic light scattering with size exclusion chromatography in order to perform Absolute Size Exclusion Chromatography. This technique allows protein size to be measured directly without the need for column calibration. Molecular weight standards are no longer required to identify oligomeric species or to determine protein purity.

The flow cell in the Zetasizer is connected after the last detector in a size exclusion chromatography system. The software makes the entire measurement process simple and straightforward. For the majority of protein separations no extra parameters are required. Size is plotted in real time as material is eluted from the column. The molecular weight of each peak is calculated automatically at the end of the measurement.

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